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Doctor beats cancer using his own treatment

<p>Australian doctor Richard Scolyer has been declared cancer free, thanks to a first-of-its-kind treatment he helped to develop.</p> <p>The 56-year-old professor, who has been recognised around for the world for his pioneering melanoma research, was diagnosed with aglioblastoma, a terminal kind of brain tumour, after suffering a seizure last June.</p> <p>After receiving his devastating diagnosis, the doctor agreed to be a "guinea pig" to undergo a world-first cancer treatment that he had a hand in developing. </p> <p>Now the world-leading pathologist and Australian of the Year has given a remarkable update, stating he is cancer free.</p> <p>“I had brain #MRI scan last Thursday looking for recurrent #glioblastoma (&amp;/or treatment complications). I found out yesterday that there is still no sign of recurrence. I couldn’t be happier!!!!!” the professor shared on X, formerly known as Twitter.</p> <p>Before Dr Scolyer was diagnosed with cancer, he was fit and active, and had been hiking mountains in Poland with his wife.</p> <p>“I felt normal. I didn’t have any symptoms at all,” he told <em>A Current Affair</em> earlier this year.</p> <p>Just days after, he suffered a devastating seizure, and when he returned to Australia, underwent a series of tests which resulted in a diagnosis with glioblastoma – an aggressive and terminal form of brain cancer that would give him a average of 14 months to live. </p> <p>Teaming up with his friend and medical oncologist Georgina Long, Scolyer decided to undergo the new treatment, which came with a long list of risks. </p> <p>“No one knew what it was going to do, people were nervous because it could actually cause my life to end more quickly. But when you’re faced with certain death, it’s a no-brainer for me,” said Professor Scolyer, who also hoped the treatment would make a difference for other cancer patients.</p> <p>Dr Scolyer also underwent surgery to remove as much of his tumour as possible, and in April, he updated his social media followers to share that10 months after his diagnosis, his tumour had not returned. </p> <p>Speaking to ABC’s <em>Australian Story</em> at the time, Professor Scolyer said he was “blown away” by the results.</p> <p>“This is not what I expected. The average time to recurrence for the nasty type of brain cancer I’ve got is six months. So, to be out this far is amazing,” he said. </p> <p><em>Image credits: Instagram</em></p>

Caring

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8 mistakes that make your hair thin

<p>Despite how many products you put load it up with, hair thins with age and there is scarcely anything that you can do to completely fight nature. What you can do is go into prevention mode as early as possible. There are many simple things that we do to our hair daily that is actually causing it a lot of stress and in many cases causing it to thin.</p> <p>So rather than a trip to the hairdresser every other week or falling for flashy and expensive products on cheap advertisements, follow these 8 simple tips to avoid damaging your hair and losing what you have.</p> <p><strong>1. Hot showers</strong></p> <p>We all know that hot water can dehydrate our skin, but did you know the same rule applies to your hair? Ryan Welter, MD, a Boston-based hair transplant surgeon explains; “Not only are you washing your hair’s protecting oils down the drain, but the heat throws your scalps pores into overdrive to keep up with oil production, which can damage the root and lead to additional shedding.”</p> <p><strong>2. Using too many heat tools</strong></p> <p>Ironic, isn’t it? All that that drying and curling we do to make our hair look fabulous is actually doing it the most damage. Not everyone is a wash-and-wear kind of person, though, so if you really can’t part with your heated tools, make sure you prep your strands with a heat protection spray. Also, they may be more expensive but ceramic plated tools are ten times better for your hair. The ceramic plate has a uniform heating system that makes it impossible for it to overheat and cause damage to the hair from burning. Additionally, you’ll get a better aesthetic result.</p> <p><strong>3. Crash dieting</strong></p> <p>Your diet affects everything, so it’s no surprise it effects your hair. Under eating forces, the body to direct the little energy it has to perform essential functions –like helping your heart pump blood-so generating new hair falls by the wayside. The good news is that you can eat certain foods for positive hair health. Lean protein like fish, chicken, lentil and beans all promote growth. Hair is primarily made of protein so it will make or break your hair. You should aim for about 46 grams per day.</p> <p><strong>4. Styling when wet</strong></p> <p>Our strands are never more fragile, and prone to breakage, than when they’re saturated with H20 – this is because the protective cuticle is slightly raised. Brushing or combing locks in the shower, then following with aggressive towel-drying and prompt styling is a recipe for swift breakages. To avoid this, let your hair dry as naturally as possible when you get out of the shower and wait patiently before styling.</p> <p><strong>5. Let’s talk about the colour</strong></p> <p>If your hair is dyed, and especially if it’s bleached, you will be more prone to breakage. However, there are many ways to avoid this. If you can’t be bothered fussing with various different treatments, simply leave your conditioner on for a few minutes rather than washing straight out. This will act like a hair treatment or mask without the hefty price tag. Alternatively, Moroccan oil is naturally high in fatty acids and vitamin E, making it a good treatment for damaged hair. Use sparingly on the ends, it only takes a few minutes to apply.</p> <p><strong>6. Opting for tight hairstyles</strong></p> <p>If you wear your hair back in a tight hairstyle, like a ponytail or bun, chances are it’s contributing to your thinning hair. Pulling on the hair follicles too tightly puts tension on them, damaging them and creating scars that destroy them permanently. This can lead to alopecia, a condition that permanently weakens the follicle and makes it impossible for hair to grow again.  </p> <p><strong>7. Over-shampooing</strong></p> <p>The purpose of shampooing your hair is to cleanse the hair and scalp of oil and product build up. However, there is actually such thing as over-shampooing. This can wash away your hairs natural moisture that helps your hair look healthy and dries it out. This is especially true if you’re using a shampoo that’s more tropical scented foam than nutrition for your hair. So how much should you wash it? Unfortunately, there’s no specific algorithm. See what works best for you, stick to it, and always be gentle.</p> <p><strong>8. Using the wrong brush</strong></p> <p>Something as simple as using the wrong hairbrush could be doing you a world of damage. Unfortunately, the thinner your hair, the more damage brushing in general will do. Stick to coming and wide bristle brushes as to not aggravate delicate hair cells. For slick, slightly damp hair, natural-bristle brushes are best and for those who can get away with it, stick to a comb and nothing but the comb. Just be sure to check the teeth for seams or roughness.</p> <p>Finally, always go by the golden rule; if something is going to harm your skin, it’s going to harm your hair. </p> <p><em>Image credits: Shutterstock</em></p>

Beauty & Style

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Daughter's incredible gesture surprises her cancer-stricken mother

<p>A brave mother fighting cancer has burst into tears at her daughter's amazing display of solidarity, as her mum continues to battle through chemotherapy. </p> <p>Tracy Mulcahy has been fighting a devastating diagnosis of stage four high-grade ovarian cancer and had started to lose her hair after relentless chemo treatment. </p> <p>Tracy and her daughter Sophie headed to their local hairdressers, where they have become like family after seven years, where Sophie was given the task of shaving her mum's head. </p> <p>To everyone's surprise, Sophie was handed the razor and decided to shave off her own long blonde hair in an emotional display of solitary and strength.</p> <p>Both women burst into tears and held one another, while there was not a dry eye in the salon from other clients and hairdressers. </p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-permalink="https://www.instagram.com/reel/C4h63b2rZYX/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/C4h63b2rZYX/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by ⚡️SOUTH WEST BLONDE SPECIALIST ⚡️ (@bambiblonde__)</a></p> </div> </blockquote> <p>The heartwarming moment was captured by the Bambi Blonde salon and posted to their Instagram, where the post racked up hundreds of thousands of likes and comments of support from all over the world.</p> <p>"The whole salon was in tears," owner Claire Lovett said.</p> <p>Sophie has since revealed she decided to do it because she didn't want her mother to "go through this alone".</p> <p>"She means the absolute world to me. She's done everything she could to help me with any issues I've had in the past," Sophie told the Hit WA radio station.</p> <p>Tracy said her daughter's decision was "just insane", saying, "I saw her do it, and I'm like, no, please don't, please don't do this. I don't want you to go through what I'm going through."</p> <p>"I think when I sat down in that hairdresser's chair and prepared myself for the day, but when you actually sit in that chair and normally go to the hairdressers, it's obviously a positive experience." </p> <p>"And then to have to look in and see that there wasn't a lot of hair left at that point. And to see Sophie do that and sacrifice her own hair for me, it was just insane."</p> <p>The family have set up a <a href="https://www.gofundme.com/f/tracys-battle-stage-4-high-grade-ovarian-cancer?utm_campaign=p_cp+fundraiser-sidebar&amp;utm_medium=copy_link_all&amp;utm_source=customer" target="_blank" rel="noopener">GoFundMe</a> page to help with the costs of Tracy's treatment. </p> <p><em>Image credits: Instagram / GoFundMe</em></p>

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Princess of Wales and King Charles: one in two people develop cancer during their lives – the diseases and treatments explained

<p><em><a href="https://theconversation.com/profiles/gavin-metcalf-1340598">Gavin Metcalf</a>, <a href="https://theconversation.com/institutions/anglia-ruskin-university-1887">Anglia Ruskin University</a></em></p> <p>The Princess of Wales released a <a href="https://x.com/KensingtonRoyal/status/1771235267837321694?s=20">moving video message</a> on March 22 to address speculation about her health. In it, the future queen disclosed that she’d been <a href="https://www.bbc.co.uk/news/health-68641710">diagnosed with cancer</a> following tests conducted after she underwent major abdominal surgery at a clinic in London in January.</p> <p>Catherine explained that she was undergoing “preventative chemotherapy” – but emphasised that her surgery had been successful, and that she was “well” and “getting stronger every day”.</p> <p>The message was the <a href="https://www.theguardian.com/uk-news/2024/mar/22/princess-kate-cancer-royal-family-health-annus-horribilis">second announcement</a> of a royal family cancer diagnosis in recent weeks. On February 5, Buckingham Palace <a href="https://www.royal.uk/a-statement-from-buckingham-palace-5Feb24">published a statement</a> that King Charles III had been diagnosed with an undisclosed form of <a href="https://www.bbc.co.uk/news/uk-68208157">cancer, unrelated</a> to the treatment he had been receiving for an enlarged prostate.</p> <figure><iframe src="https://www.youtube.com/embed/3xzKooCaRXU?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>The statement said that he had begun “regular treatments”. The king postponed all public-facing duties during his treatment, but <a href="https://www.bbc.co.uk/news/uk-68213383">reportedly continued</a> with his “constitutional role as head of state, including completing paperwork and holding private meetings”.</p> <p>Cancer is the <a href="https://www.who.int/news-room/fact-sheets/detail/cancer">leading cause of death</a> worldwide. <a href="https://www.nhs.uk/conditions/cancer/#:%7E:text=The%20cancerous%20cells%20can%20invade,of%20cancer%20during%20their%20lifetime.">One in two</a> people will develop some form of cancer in their lifetime – so the condition will affect almost every family. However, many cancers can be cured if, as appears to be the case with the king, the condition is <a href="https://www.bbc.co.uk/news/uk-68213383">detected early</a> and treated effectively.</p> <h2>What is cancer?</h2> <p>Our bodies are made up of more than 100 billion cells, and cancer typically starts with changes in a small group of cells – or even a single one.</p> <p>We have different cell types depending upon where in the body they are and the function that the cell has. The size, amount and function of each of these cells is normally tightly regulated by genes – groups of codes held within our DNA – that instruct cells how to grow and divide.</p> <p>However, changes (mutations) to DNA can alter the way cells grow and multiply – often forming a lump, or solid tumour. Cancers can also develop in blood cells, such as white blood cell cancer which is known as leukaemia. This type of cancer does not form solid tumours; instead, the cancer builds up in the blood or sometimes the marrow in the core of bones, where blood cells are produced.</p> <p>In all, there are <a href="https://www.cancerresearchuk.org/about-cancer/what-is-cancer/how-cancer-starts/types-of-cancer#:%7E:text=For%20example%2C%20nerves%20and%20muscles,of%20cell%20they%20start%20in.">more than 200</a> types of cancer, but all start with mutations in the DNA contained within each and every cell.</p> <h2>What exactly are mutations?</h2> <p>Think of your DNA as a big recipe book, and your genes as individual recipes for making different dishes. Mutations are smudges or missing words from this recipe that can result in key ingredients not being added into the mix.</p> <figure><iframe src="https://www.youtube.com/embed/8BJ8_5Gyhg8?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>Regardless of the type of cancer or the cells from which it develops, mutations in our genes can result in a cell no longer understanding its instructions.</p> <p>These mutations can happen by chance when dividing, but can also be the result of lifestyle choices such as <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141049/">smoking</a>, <a href="https://www.ndph.ox.ac.uk/news/new-genetic-study-confirms-that-alcohol-is-a-direct-cause-of-cancer#:%7E:text=These%20mutations%20both%20disrupt%20the,aldehyde%20dehydrogenase%202%20(ALDH2).">drinking</a>, and <a href="https://www.cancer.gov/about-cancer/causes-prevention/risk/obesity/physical-activity-fact-sheet">inactivity</a>.</p> <p>Research has found that in order for a normal cell to turn into a cancerous cell, anywhere from <a href="https://www.sanger.ac.uk/news_item/1-10-mutations-are-needed-drive-cancer-scientists-find/">one to ten different mutations</a> are normally required.</p> <h2>How is cancer treated?</h2> <p>Treatment options for cancer depend on a variety of factors, including where your cancer is, how large it is, and whether it has spread to other parts of the body. The main treatments for cancer include surgery, chemotherapy, and radiotherapy.</p> <p>Chemotherapy uses drugs to target and kill cells that are rapidly dividing in our bodies. This approach is effective at targeting fast-growing cells in various cancers – but also has negative side effects. It also targets healthy cells that rapidly divide, such as hair and the cells lining our digestive system. This can lead to commonly reported <a href="https://www.nhs.uk/conditions/chemotherapy/side-effects/">side-effects</a> such as hair loss, nausea and diarrhoea.</p> <p><a href="https://www.cancerresearchuk.org/about-cancer/treatment/chemotherapy?gad_source=1&amp;gclid=Cj0KCQjw-_mvBhDwARIsAA-Q0Q6tyQxTuBzU7vVD7SHjQ5dF-fRdqnL7S74-k5LXyTqODydsrPfJVsoaAkgyEALw_wcB&amp;gclsrc=aw.ds">Chemotherapy</a> can be used both preventatively – as in the case of the princess – and therapeutically.</p> <figure><iframe src="https://www.youtube.com/embed/FkZn5u3MIiY?wmode=transparent&amp;start=0" width="440" height="260" frameborder="0" allowfullscreen="allowfullscreen"></iframe></figure> <p>Preventative chemotherapy, also known as <a href="https://www.cancer.gov/publications/dictionaries/cancer-terms/def/adjuvant-therapy">adjuvant chemotherapy</a>, is given after surgery or other primary treatments to eliminate any remaining cancer cells in the body. It aims to reduce the risk of the cancer returning (known as recurrence).</p> <p>Therapeutic chemotherapy is used as a treatment option for cancer that has spread or is well established, such as advanced-stage cancers.</p> <p><a href="https://www.cancerresearchuk.org/about-cancer/treatment/surgery/about">Surgery</a> involves the physical removal of cancerous tissues as well as nearby lymph nodes – small glands which act as filters in your body that cancers can spread through – to eliminate the tumour. Surgery is often used to remove localised cancers that haven’t spread throughout the body.</p> <p><a href="https://www.cancerresearchuk.org/about-cancer/treatment/radiotherapy">Radiotherapy</a> uses high-energy radiation beams that are able to target specific areas where tumour cells are located to destroy or shrink the tumour. Radiotherapy can be applied externally or internally.</p> <p>Chemotherapy, surgery, and radiotherapy are often combined in cancer treatment to improve outcomes for patients.</p> <p>Thanks to developments in cancer research over the last 50 years, survival rates have improved greatly – although the rate of improvement has <a href="https://news.cancerresearchuk.org/2024/02/02/world-cancer-day-2024/#:%7E:text=Improvements%20in%20cancer%20survival%20have%20slowed%20in%20recent%20years&amp;text=Survival%20increased%20three%20to%20five,consistently%20lags%20behind%20comparable%20countries.">slowed recently</a>. Cancer survival depends on various factors such as age – people under 40 have a <a href="https://www.cancer.gov/about-cancer/causes-prevention/risk/age">greater chance</a> of survival – overall health and fitness, as well as family history.</p> <h2>What you should do</h2> <p>Particular changes in your body or warning symptoms could indicate the presence of cancer. These include, but are not limited to:</p> <ul> <li>Unexplained weight loss;</li> <li>Fatigue that doesn’t improve with rest;</li> <li>Changes in bowel or bladder habits;</li> <li>Persistent cough or coughing up blood;</li> <li>Difficulty swallowing;</li> <li>Persistent pain;</li> <li>Noticing lumps, such as in a breast or testicle.</li> </ul> <p>The symptoms may not necessarily be the result of cancer. But it is important to get checked by a doctor if you notice anything out of the ordinary or have had persistent symptoms that don’t ease. Early detection and treatment can <a href="https://www.science.org/doi/full/10.1126/science.aay9040">significantly improve</a> outcomes for many types of cancer.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/226456/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/gavin-metcalf-1340598">Gavin Metcalf</a>, Cancer Biologist and Lecturer in Biomedical Science, <a href="https://theconversation.com/institutions/anglia-ruskin-university-1887">Anglia Ruskin University</a></em></p> <p><em>Image credits: Getty Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/princess-of-wales-and-king-charles-one-in-two-people-develop-cancer-during-their-lives-the-diseases-and-treatments-explained-226456">original article</a>.</em></p>

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King Charles delivers heartfelt message amidst cancer treatment

<p>In times of adversity, the power of unity and compassion shines through, and this sentiment has never been more evident than in the heartfelt message delivered by King Charles amidst his cancer treatment.</p> <p>As news of his diagnosis spread, an outpouring of support enveloped the King from all corners of the Commonwealth. His gratitude and appreciation for this unwavering kindness were palpable as he addressed the nations in a video message, unable to personally attend the 2024 Commonwealth Day celebrations due to his health.</p> <p>"I have been most deeply touched by your wonderfully kind and thoughtful good wishes for my health and, in return, can only continue to serve you, to the best of my ability, throughout the Commonwealth," he said.</p> <p>"My belief in our shared endeavours and in the potential of our people remains as sure and strong as it has ever been. I have no doubt that we will continue to support one another across the Commonwealth as, together, we continue this vital journey."</p> <p>The absence of the Princess of Wales, still in recovery from surgery, served as a reminder of the fragility of life and the importance of cherishing every moment with loved ones. In such moments, the strength of familial bonds and the support of a caring community become invaluable lifelines.</p> <p>As we celebrate the 75th anniversary of the Commonwealth, we reflect not only on its historical significance but also on its enduring relevance in today's world. The theme of "One Resilient Common Future: Transforming our Commonwealth" resonates deeply as we navigate the challenges of the modern age together.</p> <p>King Charles' words remind us of the interconnectedness of our shared humanity, transcending borders and differences. He likened the Commonwealth to the wiring of a house, where each nation contributes to the collective energy and strength that sustains us all:</p> <p>"As I have said before, the Commonwealth is like the wiring of a house, and its people, our energy and our ideas are the current that runs through those wires. Together and individually we are strengthened by sharing perspectives and experiences, and by offering and borrowing the myriad ways we have each tackled the challenges of our time. This is true both at the level of nations and, indeed, at the local level. We recognise today that our diversity is our greatest strength."</p> <p>In facing global challenges such as climate change, biodiversity loss and socioeconomic shifts, the importance of collaboration and cooperation cannot be overstated. King Charles eloquently underscored the power of diversity as our greatest strength, recognising that it is through our varied perspectives and experiences that we find innovative solutions to complex problems.</p> <p><iframe title="YouTube video player" src="https://www.youtube.com/embed/lR6Z8ss_AW0?si=Gf8lGHmG-xnw9zCP" width="560" height="315" frameborder="0" allowfullscreen="allowfullscreen"></iframe></p> <p><em>Image: Youtube</em></p>

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Sarah Ferguson diagnosed with malignant melanoma – here are the latest treatments for this increasingly common skin cancer

<p><em><a href="https://theconversation.com/profiles/sarah-allinson-137762">Sarah Allinson</a>, <a href="https://theconversation.com/institutions/lancaster-university-1176">Lancaster University</a></em></p> <p>News that Sarah Ferguson, the Duchess of York, has recently been diagnosed with malignant melanoma highlights the dangers of this increasingly common skin cancer.</p> <p>Malignant melanoma affects <a href="https://www.iarc.who.int/cancer-type/skin-cancer/">325,000 people worldwide</a> every year. While it’s not the most common form of skin cancer – typically, for every one diagnosed case of melanoma, up to ten non-melanoma skin cancers are diagnosed – it causes <a href="https://theconversation.com/skin-cancer-more-people-die-from-types-that-arent-melanoma-surprise-new-finding-215378">almost as many deaths</a>. The reason for this is because it’s far more likely to spread, or metastasise, to other sites in the body compared to non-melanoma skin cancers.</p> <p>Melanoma arises in a type of pigment-producing skin cell called a <a href="https://www.cancer.org/cancer/types/melanoma-skin-cancer/about/what-is-melanoma.html#:%7E:text=Melanoma%20is%20a%20type%20of,to%20grow%20out%20of%20control.">melanocyte</a>. These cells produce and export melanin in order to provide a protective layer in the skin which helps to screen out ultraviolet (UV) radiation.</p> <p>Mutations in genes that normally carefully regulate cell growth and survival override the controls that ensure the body only produces the cells it needs. The result is uncontrolled cellular growth, or a tumour, that normally appears as an unusual-looking mole.</p> <p>The mutations that drive the growth of a melanoma usually happen as a result of exposure to UV from the sun or from an artificial source, such as a tanning bed. We know this because when a melanoma’s genome is compared to that of a normal cell we can see a high number of mutations that have a <a href="https://www.nature.com/articles/s41586-020-1943-3">characteristic “UV signature”</a>. For this reason, melanoma skin cancers occur most frequently in people who have light-coloured skin and who are exposed to high amounts of UV.</p> <p>Non-melanoma skin cancers are also mainly caused by exposure to UV but arise from a different kind of skin cell called a keratinocyte. These are the cells that normally make up the majority of the outer part of our skin, called the epidermis. Cancers that arise from keratinocytes are less likely to spread than those that come from melanocytes – although <a href="https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/non-melanoma-skin-cancer#heading-One">they can still be fatal</a>.</p> <p>In the duchess’s case, the melanoma was discovered during treatment for breast cancer. Her dermatologist recommended that some moles be removed for biopsy during breast reconstruction surgery. After testing, one was identified as malignant melanoma.</p> <p>If the results of the biopsy show that the cancer hasn’t spread, then like the majority of patients with melanoma, the duchess will be treated with surgery. In this case the tumour will be removed along with some of the surrounding normal skin.</p> <p>The amount of normal skin removed depends on the results of the biopsy – in particular, how deep into the skin the tumour has penetrated (called the <a href="https://www.macmillan.org.uk/cancer-information-and-support/melanoma/staging-of-melanoma">Breslow thickness</a>). The normal skin will be checked for any signs that cancerous cells might have spread out of the tumour.</p> <p>For most people diagnosed with melanoma, particularly if it’s at an early stage, <a href="https://www.ncbi.nlm.nih.gov/books/NBK481850/">surgery will cure the cancer</a> and they will be able to go on with their lives. But for around <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544364/">20% of patients</a>, additional treatment will be needed. This happens if their cancer has spread further into the body or if their cancer can’t be treated surgically. The <a href="https://ascopubs.org/doi/10.1200/OP.21.00686">good news</a> for these patients is that the past decade has seen huge improvements in treatment.</p> <p>Previously the only options other than surgery were radiotherapy or non-specific chemotherapy treatments. These treatments work by affecting the ability of cells to copy their DNA, which prevents them from duplicating and causes fast-growing cancer cells to die. But because these also affect the patient’s normal cells, they were accompanied by severe side effects – and were often ineffective.</p> <p>But we now have a better understanding of the specific changes melanoma makes to cell growth pathways. This has led to the development of drugs, such as <a href="https://www.cancer.gov/news-events/cancer-currents-blog/2022/fda-dabrafenib-trametinib-braf-solid-tumors">dabrafenib</a> and <a href="https://pubchem.ncbi.nlm.nih.gov/compound/Trametinib">trametinib</a>, that specifically target cells with these altered pathways. In other words, they only target the cancerous cells.</p> <p>These drugs are much more effective and have fewer side effects than traditional chemotherapies – although about half of patients who initially respond to them relapse within a year. In these patients a few of the tumour cells survive by activating other pathways for growth and use these to <a href="https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncr.30435">regrow the tumour</a>. Promisingly, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417341/">a recent study</a> suggests that re-using these drugs after a period off them can have good results in relapsed patients.</p> <p>Another exciting development in the treatment of malignant melanoma has been the use of immunotherapies. These involve harnessing the patient’s own immune system to fight the tumour.</p> <p>One particularly successful immunotherapy approach for melanoma involves the use of drugs called checkpoint inhibitors. These prevent cancer cells from being able to hide from the body’s immune system. A <a href="https://www.ejcancer.com/article/S0959-8049(23)00694-9/fulltext">recent report</a> has highlighted how the introduction of these treatments has led to improved survival for melanoma patients.</p> <p>Although the duchess’s skin cancer was discovered while she was being treated for breast cancer, it’s unlikely that the two are related. A more likely risk factor is the duchess’s famous red hair. People with red hair and pale skin that tends to freckle and burn in the sun are at a greater risk of developing skin cancer because their skin produces <a href="https://medlineplus.gov/genetics/gene/mc1r/#conditions">less melanin</a>. This means that their melanocytes are exposed to higher levels of UV and are more likely to undergo cancer-causing mutations.</p> <p>While melanoma is much more common in people with the duchess’s skin type, it’s important to be aware that anyone can get it. It’s a good idea to regularly check your skin for unusual looking moles and to contact a doctor for advice if you have a mole with any of the so-called <a href="https://www.cancerresearchuk.org/about-cancer/melanoma/symptoms">ABCDE characteristics</a>: such as an asymmetrical shape, irregular, blurred or jagged border, uneven colour, is more than 6mm wide and is evolving (either in size, texture or even bleeding).<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/221647/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/sarah-allinson-137762">Sarah Allinson</a>, Professor, Department of Biomedical and Life Sciences, <a href="https://theconversation.com/institutions/lancaster-university-1176">Lancaster University</a></em></p> <p><em>Image credits: Getty </em><em>Images </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/sarah-ferguson-diagnosed-with-malignant-melanoma-here-are-the-latest-treatments-for-this-increasingly-common-skin-cancer-221647">original article</a>.</em></p>

Body

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From straight to curly, thick to thin: here’s how hormones and chemotherapy can change

<p><em><a href="https://theconversation.com/profiles/theresa-larkin-952095">Theresa Larkin</a>, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p>Head hair comes in many colours, shapes and sizes, and hairstyles are often an expression of personal style or cultural identity.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36631178/">Many different genes</a> determine our hair texture, thickness and colour. But some people’s hair changes around the time of puberty, pregnancy or after chemotherapy.</p> <p>So, what can cause hair to become curlier, thicker, thinner or grey?</p> <h2>Curly or straight? How hair follicle shape plays a role</h2> <p>Hair is made of <a href="https://my.clevelandclinic.org/health/body/23204-keratin">keratin</a>, a strong and insoluble protein. Each hair strand grows from its own <a href="https://www.ncbi.nlm.nih.gov/books/NBK470321/">hair follicle</a> that extends deep into the skin.</p> <p>Curly hair forms due to asymmetry of both the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894537/">hair follicle and the keratin</a> in the hair.</p> <p>Follicles that produce <a href="https://www.medicalnewstoday.com/articles/318524">curly hair</a> are asymmetrical and curved and lie at an angle to the surface of the skin. This kinks the hair as it first grows.</p> <p>The asymmetry of the hair follicle also causes the keratin to bunch up on one side of the hair strand. This pulls parts of the hair strand closer together into a curl, which maintains the curl as the hair continues to grow.</p> <p>Follicles that are symmetrical, round and perpendicular to the skin surface produce straight hair.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=600&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=600&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=600&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=754&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=754&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/567020/original/file-20231221-29-fp0wci.jpg?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=754&amp;fit=crop&amp;dpr=3 2262w" alt="A diagram shows the hair follicle shape of straight, curly and coiled hair." /></a><figcaption><span class="caption">Each hair strand grows from its own hair follicle.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-vector/diagram-hair-follicle-shape-vector-illustration-2248429145">Mosterpiece/Shutterstock</a></span></figcaption></figure> <h2>Life changes, hair changes</h2> <p>Our hair undergoes repeated cycles throughout life, with different stages of growth and loss.</p> <p>Each hair follicle contains stem cells, which multiply and <a href="https://www.frontiersin.org/articles/10.3389/fcell.2022.899095/full">grow into a hair strand</a>.</p> <p>Head hairs spend most of their time in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905671/">the growth phase</a>, which can last for several years. This is why head hair can grow so long.</p> <p>Let’s look at the life of a single hair strand. After the growth phase is a transitional phase of about two weeks, where the hair strand stops growing. This is followed by a resting phase where the hair remains in the follicle for a few months before it <a href="https://www.healthline.com/health/stages-of-hair-growth">naturally falls out</a>.</p> <p>The hair follicle <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/exd.13347">remains in the skin</a> and the stems cells grow a new hair to repeat the cycle.</p> <p>Each hair on the scalp is replaced <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606321/#b3">every three to five years</a>.</p> <h2>Hormone changes during and after pregnancy alter the usual hair cycle</h2> <p>Many women notice their hair is <a href="https://www.medicalnewstoday.com/articles/pregnancy-hair">thicker during pregnancy</a>.</p> <p>During pregnancy, high levels of <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908443/">oestrogen, progesterone and prolactin</a> prolong the resting phase of the hair cycle. This means the hair <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432488/">stays in the hair follicle for longer</a>, with less hair loss.</p> <p>A drop in hormones a few months after delivery causes increased hair loss. This is due to all the hairs that remained in the resting phase during pregnancy falling out in a fairly synchronised way.</p> <h2>Hair can change around puberty, pregnancy or after chemotherapy</h2> <p>This is related to the genetics of hair shape, which is an example of <a href="https://www.biologyonline.com/dictionary/incomplete-dominance">incomplete dominance</a>.</p> <p>Incomplete dominance is when there is a middle version of a trait. For hair, we have curly hair and straight hair genes. But when someone has one curly hair gene and one straight hair gene, they can have wavy hair.</p> <p>Hormonal changes that occur around <a href="https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-019-0780-4">puberty</a> and <a href="https://www.mdpi.com/1422-0067/23/20/12698">pregnancy</a> can affect the function of genes. This can cause the curly hair gene of someone with wavy hair to become more active. This can change their hair from wavy to curly.</p> <p>Researchers have identified that activating specific genes can change hair in pigs <a href="https://www.frontiersin.org/articles/10.3389/fgene.2023.1184015/full">from straight to curly</a>.</p> <p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5759815/">Chemotherapy</a> has very visible effects on hair. Chemotherapy kills rapidly dividing cells, <a href="https://jamanetwork.com/journals/jamaoncology/fullarticle/2628766">including hair follicles</a>, which causes hair loss. Chemotherapy can also have <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988866/">genetic effects</a> that influence hair follicle shape. This can cause hair to <a href="https://www.medicalnewstoday.com/articles/chemo-curls">regrow with a different shape</a> for the first few cycles of hair regrowth.</p> <h2>Hormonal changes as we age also affect our hair</h2> <p>Throughout life, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432488/">thyroid hormones</a> are essential for production of keratin. Low levels of thyroid hormones can cause dry and brittle hair.</p> <p><a href="https://pubmed.ncbi.nlm.nih.gov/36578854/">Oestrogen and androgens</a> also regulate hair growth and loss, particularly as we age.</p> <p>Balding in males is due to <a href="https://theconversation.com/starting-to-thin-out-hair-loss-doesnt-have-to-lead-to-baldness-34984">higher levels of androgens</a>. In particular, high dihydrotestosterone (sometimes shortened to DHT), which is produced in the body from testosterone, has a role in <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7269836/">male pattern baldness</a>.</p> <p>Some women experience <a href="https://theconversation.com/health-check-why-does-womens-hair-thin-out-39126">female pattern hair loss</a>. This is caused by a combination of genetic factors plus lower levels of <a href="https://www.mdpi.com/2077-0383/12/3/893">oestrogen and higher androgens</a> after menopause. The hair follicles become smaller and smaller until they no longer produce hairs.</p> <p>Reduced function of the cells that produce <a href="https://www.health.com/mind-body/what-going-gray-early-can-tell-you-about-your-health">melanin</a> (the pigment that gives our hair colour) is what causes greying.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/219329/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><a href="https://theconversation.com/profiles/theresa-larkin-952095"><em>Theresa Larkin</em></a><em>, Associate professor of Medical Sciences, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p><em>Image credits: </em><em>Shutterstock </em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/from-straight-to-curly-thick-to-thin-heres-how-hormones-and-chemotherapy-can-change-your-hair-219329">original article</a>.</em></p>

Caring

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How can I get some sleep? Which treatments actually work?

<p><em><a href="https://theconversation.com/profiles/alexander-sweetman-1331085">Alexander Sweetman</a>, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a>; <a href="https://theconversation.com/profiles/jen-walsh-1468594">Jen Walsh</a>, <a href="https://theconversation.com/institutions/the-university-of-western-australia-1067">The University of Western Australia</a>, and <a href="https://theconversation.com/profiles/nicole-grivell-1468590">Nicole Grivell</a>, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a></em></p> <p>Do you have difficulty falling asleep? Do you stay awake for a long time at night? Do these sleep problems make you feel fatigued, strung-out, or exhausted during the day? Has this been happening for months?</p> <p>If so, you’re not alone. About <a href="https://www.sleephealthfoundation.org.au/special-sleep-reports/chronic-insomnia-disorder-in-australia">12-15%</a> of Australian adults have chronic insomnia.</p> <p>You might have tried breathing exercises, calming music, white noise, going to bed in a dark and quiet bedroom, eating different foods in the evening, maintaining a regular sleep pattern, or reducing caffeine. But after three to four weeks of what seems like progress, your insomnia returns. What next?</p> <h2>What not to do</h2> <p>These probably won’t help:</p> <ul> <li> <p><strong>spending more time in bed</strong> often results in more time spent <em>awake</em> in bed, which can make <a href="https://theconversation.com/how-do-i-stop-my-mind-racing-and-get-some-sleep-207904">insomnia patterns worse</a></p> </li> <li> <p><strong>drinking coffee and taking naps</strong> might help get you through the day. But <a href="https://theconversation.com/nope-coffee-wont-give-you-extra-energy-itll-just-borrow-a-bit-that-youll-pay-for-later-197897">caffeine</a> stays in the system for many hours, and can disrupt our sleep if you drink too much of it, especially after about 2pm. If naps last for more than 30 minutes, or occur after about 4pm, this can reduce your “sleep debt”, and can make it <a href="https://theconversation.com/why-do-i-fall-asleep-on-the-sofa-but-am-wide-awake-when-i-get-to-bed-208371">more difficult</a> to fall asleep in the evening</p> </li> <li> <p><strong>drinking alcohol</strong> might help you fall asleep quicker, but <a href="https://journals.sagepub.com/doi/10.1300/J465v26n01_01">can cause</a> more frequent awakenings, change how long you sleep, change the time spent in different “stages” of sleep, and reduce the overall quality of sleep. Therefore, it is not recommended as a sleep aid.</p> </li> </ul> <h2>What to do next?</h2> <p>If your symptoms have lasted more than one or two months, it is likely your insomnia requires targeted treatments that focus on sleep patterns and behaviours.</p> <p>So, the next stage is a type of non-drug therapy known as cognitive behavioural therapy for insomnia (or <a href="https://www.sleepprimarycareresources.org.au/insomnia/cbti">CBTi</a> for short). This is a four to eight week treatment that’s been shown to be <a href="https://doi.org/10.1016/j.smrv.2022.101687">more effective</a> than sleeping pills.</p> <p>It involves education about sleep, and offers psychological and behavioural treatments that address the underlying causes of long-term insomnia.</p> <p>You can do this one-on-one, in a small group with health professionals trained in CBTi, or via self-guided <a href="https://www.sleepprimarycareresources.org.au/insomnia/cbti/referral-to-digital-cbti-programs">online programs</a>.</p> <p>Some GPs are trained to offer CBTi, but it’s more usual for specialist <a href="https://psychology.org.au/find-a-psychologist">sleep psychologists</a> to offer it. Your GP can refer you to one. There are some Medicare rebates to subsidise the cost of treatment. But many psychologists will also charge a gap fee above the Medicare subsidy, making access to CBTi a challenge for some.</p> <p><a href="https://doi.org/10.12703%2Fr%2F11-4">About 70-80%</a> of people with insomnia sleep better after CBTi, with improvements lasting <a href="https://doi.org/10.1016/j.smrv.2019.08.002">at least a year</a>.</p> <h2>What if that doesn’t work?</h2> <p>If CBTi doesn’t work for you, your GP might be able to refer you to a specialist sleep doctor to see if other sleep disorders, such as <a href="https://doi.org/10.1016/j.smrv.2016.04.004">obstructive sleep apnoea</a>, are contributing to your insomnia.</p> <p>It can also be important to manage any mental health problems such as <a href="https://doi.org/10.5694/mja2.51200">depression and anxiety</a>, as well as physical symptoms such as pain that can also disrupt sleep.</p> <p>Some lifestyle and work factors, such as shift-work, might also require management by a specialist sleep doctor.</p> <h2>What about sleeping pills?</h2> <p>Sleeping pills are <a href="https://www.sleepprimarycareresources.org.au/insomnia/pharmacological-therapy">not the recommended</a> first-line way to manage insomnia. However, they do have a role in providing short-term, rapid relief from insomnia symptoms or when CBTi is not accessible or successful.</p> <p>Traditionally, medications such as benzodiazepines (for example, temazepam) and benzodiazepine receptor agonists (for example, zolpidem) have been used to help people sleep.</p> <p>However, these can have <a href="https://doi.org/10.1136/bmj.38623.768588.47">side-effects</a> including a risk of falls, being impaired the next day, as well as tolerance and dependence.</p> <p>Melatonin – either prescribed or available from pharmacies for people aged 55 and over – is also often used to manage insomnia. But the <a href="https://doi.org/10.1016/j.smrv.2022.101692">evidence suggests</a> it has limited benefits.</p> <h2>Are there new treatments? How about medicinal cannabis?</h2> <p>Two newer drugs, known as “orexin receptor antagonists”, are available in Australia (suvorexant and lemborexant).</p> <p>These block the wake-promoting pathways in the brain. <a href="https://doi.org/10.4088/PCC.22nr03385">Early data suggests</a> they are effective in improving sleep, and have lower risk of potential side-effects, tolerance and dependence compared with earlier medicines.</p> <p>However, we don’t know if they work or are safe over the long term.</p> <p><a href="https://doi.org/10.1093/sleep/zsab149">Medicinal cannabis</a> <a href="https://doi.org/10.1111/jsr.13793">has only in recent years</a> <a href="https://doi.org/10.1093/sleepadvances/zpac029.048">been studied</a> as a treatment for <a href="https://doi.org/10.1093/sleepadvances/zpac029.005">insomnia</a>.</p> <p>In an Australian survey, <a href="https://doi.org/10.2147/nss.s390583">more than half</a> of people using medicinal cannabis said they used it to treat insomnia. There are reports of <a href="https://doi.org/10.1371/journal.pone.0272241">significant benefit</a>.</p> <p>But of the four most robust studies so far, <a href="https://doi.org/10.1093/sleep/zsab149">only one</a> (led by one of us, Jen Walsh) has demonstrated an improvement in insomnia after two weeks of treatment.</p> <p>So we need to learn more about which cannabinoids – for example, delta-9-tetrahydrocannabinol, cannabidiol or cannabinol – and which doses may be beneficial. We also need to learn who can benefit most, and whether these are safe and effective over the long term.</p> <h2>What now?</h2> <p>If you’ve had trouble sleeping for a short time (under about a month) and nothing you try is working, there may be underlying reasons for your insomnia, which when treated, can provide some relief. Your GP can help identify and manage these.</p> <p>Your GP can also help you access other treatments if your insomnia is more long term. This may involve non-drug therapies and/or referral to other services or doctors.</p> <hr /> <p><em>For more information about insomnia and how it’s treated, see the Sleep Health Foundation’s <a href="https://www.sleephealthfoundation.org.au/sleep-disorders/insomnia-2">online resource</a>.</em><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/212964/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/alexander-sweetman-1331085">Alexander Sweetman</a>, Research Fellow, College of Medicine and Public Health, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a>; <a href="https://theconversation.com/profiles/jen-walsh-1468594">Jen Walsh</a>, Director of the Centre for Sleep Science, <a href="https://theconversation.com/institutions/the-university-of-western-australia-1067">The University of Western Australia</a>, and <a href="https://theconversation.com/profiles/nicole-grivell-1468590">Nicole Grivell</a>, Research Coordinator and final year PhD Candidate at FHMRI Sleep Health, <a href="https://theconversation.com/institutions/flinders-university-972">Flinders University</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-can-i-get-some-sleep-which-treatments-actually-work-212964">original article</a>.</em></p>

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Why does my hair turn green from the swimming pool?

<p><em><a href="https://theconversation.com/profiles/magdalena-wajrak-1432339">Magdalena Wajrak</a>, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a></em></p> <p>If you are a blonde like me and enjoy laps in a swimming pool, you may have noticed your hair acquires a green tint after frequent swims in chlorinated water.</p> <p>This happens to both bleached and natural blondes. In fact, the green tinge happens to everyone, but it’s less visible on dark hair and those whose hair isn’t damaged by chemical treatments such as bleaching.</p> <p>But what exactly causes this green discoloration, and what can we do about it? Most of us blame the chlorine in the pool water. However, although chlorine does play a part, it is not the main culprit.</p> <h2>Which chemicals in the pool turn the hair green?</h2> <p>The element to blame for the green staining of hair is copper.</p> <p>The main source of copper is copper sulfate (CuSO₄), a compound added to swimming pools to prevent the growth of algae. <a href="https://www.sciencedirect.com/science/article/pii/S1568988320301803?via%3Dihub">Contact with algae</a> can cause skin irritation and respiratory issues, and ingesting water with algae can lead to serious gastrointestinal problems. Only a small amount (around 0.5mg per litre or 0.5 parts per million) of copper sulfate is needed to prevent algal growth.</p> <p>However, copper can also enter swimming pools through the corrosion of water pipes, so concentrations may be higher in some pools.</p> <p>Copper sulfate crystals are greenish-blue in colour. So, when hair comes into contact with copper ions – a positively charged variant of a copper atom with extra electrons – those ions get absorbed by the hair and cause the greenish hue.</p> <p>Scientists were fascinated by the green “pool hair” phenomenon as far back as the 1970s, so we actually have research data on copper being the cause.</p> <p>One very <a href="https://jamanetwork.com/journals/jamadermatology/article-abstract/538197">interesting study in 1978</a> performed experiments by immersing hair samples into water containing different concentrations of copper ions, chlorine and various pH values (neutral and basic). Their results showed hair exposed to free copper ions does turn green.</p> <p>Furthermore, when hair is oxidised (meaning electrons are removed from the hair proteins) by chlorine, it actually damages the hair, enhancing the absorption of copper ions. Hair submerged in water with chlorine but without copper ions did not turn green. Meanwhile, hair exposed to water with only copper ions and no chlorine still formed a green colour.</p> <p>Hence, chlorine by itself does not play a role in causing the green hue we see in “pool hair”, but it does exacerbate it.</p> <h2>So, how does copper get into the hair?</h2> <p><a href="https://doi.org/10.1007/978-1-4684-0943-7_24">Other research teams</a> have conducted <a href="https://doi.org/10.1071/ch9682437">more extensive studies</a>, using sophisticated instruments, such as scanning electron microscopy, to examine how exactly copper ions attach to the hair.</p> <p>Our hair is predominantly composed of protein called keratin. Keratin is classified as a “structural fibrous protein”, meaning it has an elongated, sheet-like structure.</p> <p>The keratin structure is composed of various <a href="https://chem.libretexts.org/Courses/University_of_Kentucky/UK%3A_CHE_103_-_Chemistry_for_Allied_Health_(Soult)/Chapters/Chapter_4%3A_Structure_and_Function/4.4%3A_Functional_Groups">chemical groups</a> (types of atom groupings with similar properties), such as carboxyl groups, amino groups and disulfide groups. Copper ions have the ability to form bonds with these groups, forming a copper-keratin complex. This complex remains in the hair, causing it to appear green.</p> <p>Interestingly, the most recent study <a href="https://doi.org/10.32657/10356/142466">conducted in 2020</a>, showed copper ions mainly bind to the disulfide groups. This study also found other metal ions such as zinc, lead, chromium and mercury also bind to hair in the same way. This is very useful in <a href="https://theconversation.com/forensic-breakthrough-study-suggests-humans-can-be-identified-by-the-proteins-in-their-hair-65051">forensic analysis</a>, for example, because forensic scientists can analyse hair samples to determine if a person has been exposed to a particular metal.</p> <p>Light-coloured hair already has the most visible green discoloration, but research has shown that damaged hair, caused by bleaching, straightening, or exposure to sun, is the <a href="https://pubmed.ncbi.nlm.nih.gov/19586601/">most susceptible</a> to the binding of copper ions. This is because in damaged hair the disulfide groups have “broken bonds” (the link that holds the elements within these groups together is broken), making it easier for the copper ions to bind to the hair.</p> <h2>Can I prevent the green colour or get rid of it?</h2> <p>To prevent your hair from turning green in a swimming pool, you have two basic options. The first is a physical barrier – just wear a swim cap.</p> <p>The second option is chemical – you can pre-treat your hair with an alkaline shampoo. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0891584918310050">Studies have shown</a> under alkaline pH conditions, the copper ions won’t attach to the hair. To treat your hair before going to the pool, you can either use a shampoo with a pH higher than 7, or you can even try mixing some baking soda into your regular shampoo.</p> <p>But what can you do if your hair has already turned greenish? Well, you can try washing your hair with a shampoo designed to achieve this, typically marketed as a “chlorine removal” shampoo. These products contain a chemical called EDTA – it can bind to metal ions (such as copper) and thus will remove copper from the hair.</p> <p>You may have heard tomato sauce or ketchup is a good way to get the green out of your pool hair – potentially because the red pigments are supposed to “cancel out” the green ones. However, I’m not aware of any scientific evidence this would work.</p> <p><em>Correction: This article has been amended to clarify that alkaline shampoos have a pH higher than 7, not lower.</em><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/211736/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><a href="https://theconversation.com/profiles/magdalena-wajrak-1432339"><em>Magdalena Wajrak</em></a><em>, Senior lecturer, Chemistry, <a href="https://theconversation.com/institutions/edith-cowan-university-720">Edith Cowan University</a></em></p> <p><em>Image </em><em>credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/why-does-my-hair-turn-green-from-the-swimming-pool-211736">original article</a>.</em></p>

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How do hay fever treatments actually work? And what’s best for my symptoms?

<p><em><a href="https://theconversation.com/profiles/mary-bushell-919262">Mary Bushell</a>, <a href="https://theconversation.com/institutions/university-of-canberra-865">University of Canberra</a></em></p> <p>Spring has sprung and many people are welcoming longer days and more time outdoors. But for <a href="https://www.aihw.gov.au/reports/chronic-respiratory-conditions/allergic-rhinitis-hay-fever/contents/allergic-rhinitis">almost one in five Australians</a>, spring also brings the misery of watery, itchy red eyes, a runny, congested nose, and sneezing.</p> <p>Hay fever (also known as allergic rhinitis) is caused when an allergen enters the nose or eyes. Allergens are harmless airborne substances the body has incorrectly identified as harmful. This triggers an immune response, which leads to the release of inflammatory chemicals (mediators) – one of which is histamine.</p> <p>Allergens that trigger hay fever differ from person to person. Common seasonal allergens include tree, grass and weed pollens (year-round allergens include dust mites, mould and pet dander). It’s now <a href="https://www.sciencedirect.com/science/article/pii/S132602002302191X">pollen season</a> in many parts of Australia, with pollen counts at their highest and hay fever cases surging.</p> <p>So what medicines can prevent or reduce hay fever symptoms, and how do they work?</p> <h2>Antihistamines</h2> <p>Knowing the release of histamine is a cause of hay fever symptoms, it’s unsurprising that <em>anti</em>-histamines are one of the most frequently recommended medicines to treat hay fever.</p> <p>Antihistamines block histamine from binding to histamine receptors in the body and having an effect, reducing symptoms.</p> <p>In Australia, we broadly have two types. The older sedating (introduced in the <a href="https://www.tga.gov.au/news/safety-alerts/first-generation-antihistamines-winter-warning">1940s</a>) and newer, less-sedating (introduced in the 1980s) antihistamines.</p> <p>Less-sedating antihistamines used to treat allergic rhinitis include bilastine (Allertine), cetirizine (Zyrtec), loratadine (Claratyne) and fexofenadine (Telfast). Bilastine, which came onto the Australian market only last year, is only available from a pharmacy, on recommendation from a pharmacist. The others have been around longer and are available at supermarkets and in larger quantities from pharmacies. Cetirizine is the <a href="https://www.tga.gov.au/resources/publication/scheduling-decisions-interim/scheduling-delegates-interim-decisions-and-invitation-further-comment-accsacms-november-2016/35-cetirizine-hydrochloride#:%7E:text=Risks%20of%20cetirizine%20hydrochloride%20use,significant%20at%20the%20proposed%20doses.">most likely</a> (of the less-sedating antihistamines) to cause sedation.</p> <p>The older sedating antihistamines (such as promethazine) cross the blood-brain barrier, causing drowsiness and even brain fog the next day. They have lots of side effects and potential drug interactions, and as such have little place in the management of hay fever.</p> <p>The newer less-sedating antihistamines are <a href="https://australianprescriber.tg.org.au/articles/antihistamines-and-allergy.html#:%7E:text=Less%20sedating%20antihistamines%20are%20equally,an%20ongoing%20good%20safety%20profile">equally effective</a> as the older sedating ones.</p> <p>Antihistamines are usually taken orally (as a tablet or solution) but there are also topical preparations such as nasal sprays (azelastine) and eye drops. Antihistamine nasal sprays have <a href="https://www.sciencedirect.com/science/article/abs/pii/S108112061000743X">equal to or better efficacy</a> than oral antihistamines.</p> <p>The individual response to antihistamines varies widely. For this reason, you may need to trial several different types of antihistamines to see which one works best for you.</p> <p>Increasing the dose of an antihistamine, or combining an oral and topical antihistamine, does not provide any additional benefit. Paying extra for a brand name doesn’t offer any more or less effect than the generic (both have the same active ingredient and are <a href="https://www.tga.gov.au/news/news/generic-prescription-medicines-fact-sheet">bioequivalent</a>, which means they have the same outcomes for patients).</p> <h2>Steroid nasal sprays</h2> <p>If your symptoms don’t improve from antihistamines alone, a nasal spray containing a corticosteroid is often recommended.</p> <p>Corticosteroids prevent the release of several key chemicals that cause inflammation. How they work is complex: in part, corticosteroids “turn off” the production of late phase inflammatory mediators (cytokines and chemokines). This reduces the future release of more inflammatory mediators, which reduces inflammation.</p> <p>Corticosteroids and antihistamines have different mechanisms of action. Research shows corticosteroid nasal sprays are <a href="https://journals.sagepub.com/doi/full/10.2500/ajra.2016.30.4397">more effective</a> than antihistamines in controlling an itchy, runny, congested nose. But when instilled into the nose, corticosteroids <a href="https://aao-hnsfjournals.onlinelibrary.wiley.com/doi/10.1016/j.otohns.2007.10.027">also reduce</a> the eye symptoms of hay fever.</p> <p>There are also nasal sprays that contain both an antihistamine and corticosteroid.</p> <p>While there are a range of corticosteroid nasal sprays containing different active ingredients, a large study published this year shows they are all <a href="https://www.frontiersin.org/articles/10.3389/fphar.2023.1184552/full">about as effective as each other</a>, and work best when they have been taken for several days.</p> <h2>Sodium cromoglycate</h2> <p>Another medicine used to treat hay fever symptoms is sodium cromoglycate, which is available as an eye drop and over-the-counter in pharmacies.</p> <p>This medicine is known as a mast cell stabiliser. As the name suggests, it stabilises or prevents mast cells from breaking down. When mast cells break down, they release histamine and other chemicals that cause inflammation.</p> <p>This eye drop is both a preventative and treatment medicine, usually used before allergies strike. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9375451/">Evidence shows</a> it is effective at reducing the symptoms of allergic conjunctivitis (eye inflammation from allergies).</p> <h2>Decongestants</h2> <p>Decongestants constrict blood vessels. They can be taken orally, administered as a nasal spray, or instilled into the eyes. When administered into the eyes it will reduce redness, and when administered into the nose, it will stop it from running.</p> <p>However, decongestants should be used for a short duration only and are not for long term use. In fact, if a nasal spray decongestant is used for more than five days, you can experience something called “rebound congestion”: a severe stuffy nose.</p> <h2>Saline</h2> <p>Saline (saltwater) nasal sprays or irrigation products are also available to flush out the allergens and provide hay fever relief. While there are not many studies in the area, there is evidence that saline irrigation <a href="https://www.cochrane.org/CD012597/ENT_nasal-saline-allergic-rhinitis#:%7E:text=Saline%20irrigation%20may%20reduce%20patient,any%20outcomes%20beyond%20three%20months">may reduce hay fever symptoms</a>. Saline is safe and is not associated with adverse effects.</p> <p>If you’re suffering from hay fever symptoms and unsure what to try, talk to your prescriber or pharmacist, who can guide you through the options and identify the best one for your symptoms, medical conditions and medicines.</p> <p>Allergen immunotherapy (or allergen shots) is another option hay fever sufferers <a href="https://www.allergy.org.au/patients/allergy-treatments/allergen-immunotherapy-faqs">may discuss</a> with their doctors. However it’s not a quick fix, with therapy taking three to five years.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/213071/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/mary-bushell-919262">Mary Bushell</a>, Clinical Assistant Professor in Pharmacy, <a href="https://theconversation.com/institutions/university-of-canberra-865">University of Canberra</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/how-do-hay-fever-treatments-actually-work-and-whats-best-for-my-symptoms-213071">original article</a>.</em></p>

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Taking an antidepressant? Mixing it with other medicines – including some cold and flu treatments – can be dangerous

<p><em><a href="https://theconversation.com/profiles/treasure-mcguire-135225">Treasure McGuire</a>, <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p>In the depths of winter we are more at risk of succumbing to <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522168/">viral respiratory infections</a> – from annoying sore throat, common cold and sinusitis, to the current resurgence of respiratory syncytial virus (RSV), influenza and COVID.</p> <p>Symptoms of upper respiratory tract infection range in severity. They can include fever, chills, muscle or body aches, cough, sore throat, runny or stuffy nose, earache, headache, and fatigue. Most antibiotics target bacteria so are <a href="https://pubmed.ncbi.nlm.nih.gov/32495003/">not effective</a> for viral infections. Many people seek relief with over-the-counter medicines.</p> <p>While evidence varies, guidelines suggest medicines taken by mouth (such as cough syrups or cold and flu tablets) have a <a href="https://pubmed.ncbi.nlm.nih.gov/25420096/">limited but potentially positive</a> short-term role for managing upper respiratory infection symptoms in adults and children older than 12. These include:</p> <ul> <li>paracetamol or ibuprofen for pain or fever</li> <li>decongestants such as phenylephrine or pseudoephedrine</li> <li>expectorants and mucolytics to thin and clear mucus from upper airways</li> <li>dry cough suppressants such as dextromethorphan</li> <li>sedating or non-sedating antihistamines for runny noses or watery eyes.</li> </ul> <p>But what if you have been prescribed an antidepressant? What do you need to know before going to the pharmacy for respiratory relief?</p> <h2>Avoiding harm</h2> <p>An audit of more than 5,000 cough-and-cold consumer enquiries to an Australian national medicine call centre found questions frequently related to drug-drug interactions (29%). An 18-month analysis showed 20% of calls <a href="https://pubmed.ncbi.nlm.nih.gov/26590496/">concerned</a> potentially significant interactions, particularly with antidepressants.</p> <p>Australia remains in the “<a href="https://www.aihw.gov.au/mental-health/topic-areas/mental-health-%20prescriptions#Prescriptionsbytype">top ten</a>” antidepressant users in the <a href="https://stats.oecd.org/Index.aspx?DataSetCode=HEALTH_PHMC">OECD</a>. More than <a href="https://www.aihw.gov.au/mental-health/topic-areas/mental-health-prescriptions">32 million</a> antidepressant prescriptions are dispensed on the Pharmaceutical Benefits Scheme each year.</p> <p>Antidepressants are commonly prescribed to manage symptoms of anxiety or depression but are also used in chronic pain and incontinence. They are classified primarily by how they affect chemical messengers in the nervous system.</p> <p>These classes are:</p> <ul> <li><strong>selective serotonin reuptake inhibitors (SSRI)</strong> such as fluoxetine, escitalopram, paroxetine and sertraline</li> <li><strong>serotonin and noradrenaline reuptake inhibitors (SNRI)</strong> such as desvenlafaxine, duloxetine and venlafaxine</li> <li><strong>tricyclic antidepressants (TCA)</strong> such as amitriptyline, doxepin and imipramine</li> <li><strong>monoamine oxidase inhibitors (MAOI)</strong> such as tranylcypromine</li> <li><strong>atypical medicines</strong> such as agomelatine, mianserin, mirtazapine, moclobemide, reboxetine and vortioxetine</li> <li><strong>complementary medicines</strong> including St John’s wort, S-adenosyl methionine (SAMe) and L-tryptophan</li> </ul> <p>Medicines within the same class of antidepressants have similar actions and side-effect profiles. But the molecular differences of individual antidepressants mean they may have different interactions with medicines taken at the same time.</p> <h2>Types of drug interactions</h2> <p>Drug interactions can be:</p> <ul> <li><strong>pharmacokinetic</strong> – what the body does to a drug as it moves into, through and out of the body. When drugs are taken together, one may affect the absorption, distribution, metabolism or elimination of the other</li> <li><strong>pharmacodynamic</strong> – what a drug does to the body. When drugs are taken together, one may affect the action of the other. Two drugs that independently cause sedation, for example, may result in excessive drowsiness if taken together.</li> </ul> <p>There are many <a href="https://wchh.onlinelibrary.wiley.com/doi/pdf/10.1002/pnp.429">potential interactions</a> between medications and antidepressants. These include interactions between over-the-counter medicines for upper respiratory symptoms and antidepressants, especially those taken orally.</p> <p>Concentrations of nasal sprays or inhaled medicines are generally lower in the blood stream. That means they are less likely to interact with other medicines.</p> <h2>What to watch for</h2> <p>It’s important to get advice from a pharmacist before taking any medications on top of your antidepressant.</p> <p>Two symptoms antidepressant users should monitor for shortly after commencing a cough or cold medicine are central nervous system effects (irritability, insomnia or drowsiness) and effects on blood pressure.</p> <p>For example, taking a selective SSRI antidepressant and an oral decongestant (such as pseudoephedrine or phenylephrine) can cause irritability, insomnia and affect blood pressure.</p> <p>Serotonin is a potent chemical compound produced naturally for brain and nerve function that can also constrict blood vessels. Medicines that affect serotonin are common and include most antidepressant classes, but also decongestants, dextromethorphan, St John’s wort, L-tryptophan, antimigraine agents, diet pills and amphetamines.</p> <p><a href="https://reference.medscape.com/drug-interactionchecker">Combining drugs</a> such as antidepressants and decongestants that both elevate serotonin levels can cause irritability, headache, insomnia, diarrhoea and blood pressure effects – usually increased blood pressure. But some people experience orthostatic hypotension (low blood pressure on standing up) and dizziness.</p> <p>For example, taking both a serotonin and SNRI antidepressant and dextromethorphan (a cough suppressant) can add up to high serotonin levels. This can also occur with a combination of the complementary medicine St John’s Wort and an oral decongestant.</p> <p>Where serotonin levels are too high, <a href="https://pubmed.ncbi.nlm.nih.gov/15666281/">severe symptoms</a> such as confusion, muscle rigidity, fever, seizures and even death have been reported. Such symptoms are rare but if you notice any of these you should stop taking the cold and flu medication straight away and seek medical attention.</p> <h2>Ways to avoid antidepressant drug interactions</h2> <p>There are a few things we can do to prevent potentially dangerous interactions between antidepressants and cold and flu treatments.</p> <p><strong>1. Better information</strong></p> <p>Firstly, there should be more targeted, consumer-friendly, <a href="https://www.webmd.com/interaction-checker/default.htm">online drug interaction information</a> available for antidepressant users.</p> <p><strong>2. Prevent the spread of viral infections as much as possible</strong></p> <p>Use the non-drug strategies that have worked well for COVID: regular hand washing, good personal hygiene, social distancing, and facemasks. Ensure adults and children are up to date with immunisations.</p> <p><strong>3. Avoid potential drug interactions with strategies to safely manage symptoms</strong></p> <p>Consult your pharmacist for strategies most appropriate for you and only use cold and flu medications while symptoms persist:</p> <ul> <li>treat muscle aches, pain, or a raised temperature with analgesics such as paracetamol or ibuprofen</li> <li>relieve congestion with a nasal spray decongestant</li> <li>clear mucus from upper airways with expectorants or mucolytics</li> <li>dry up a runny nose or watery eyes with a non-sedating antihistamine.</li> </ul> <p>Avoid over-the-counter cough suppressants for an irritating dry cough. Use a simple alternative such as honey, steam inhalation with a few drops of eucalyptus oil or a non-medicated lozenge instead.</p> <p><strong>4. Ask whether your symptoms could be more than the common cold</strong></p> <p>Could it be influenza or COVID? Seek medical attention if you are concerned or your symptoms are not improving. <img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/208662/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /></p> <p><em><a href="https://theconversation.com/profiles/treasure-mcguire-135225">Treasure McGuire</a>, Assistant Director of Pharmacy, Mater Health SEQ in conjoint appointment as Associate Professor of Pharmacology, Bond University and as Associate Professor (Clinical), <a href="https://theconversation.com/institutions/the-university-of-queensland-805">The University of Queensland</a></em></p> <p><em>Image credits: Getty Images</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/taking-an-antidepressant-mixing-it-with-other-medicines-including-some-cold-and-flu-treatments-can-be-dangerous-208662">original article</a>.</em></p>

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What is dandruff? How do I get rid of it? Why does it keep coming back?

<p><em><a href="https://theconversation.com/profiles/lorraine-mackenzie-1420658">Lorraine Mackenzie</a>, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a> and <a href="https://theconversation.com/profiles/sean-mangion-1420661">Sean Mangion</a>, <a href="https://theconversation.com/institutions/university-of-south-australia-1180"><em>University of South Australia</em></a></em></p> <p>Dandruff can be dry, like snowflakes, or greasy, with yellow clumps. <a href="https://www.ncbi.nlm.nih.gov/books/NBK551707/">Up to half</a> of all adults have had this scalp condition at one point, so you’ll no doubt know about these skin flakes and the itchiness.</p> <p>Dandruff can be <a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1439-0507.2008.01624.x">embarrassing</a>. It can affect many aspects of people’s lives, such as how they socialise, how they style their hair, and what clothes they wear.</p> <p>Dandruff is not a modern problem. In fact, it has been around for millennia and was <a href="https://pubmed.ncbi.nlm.nih.gov/2181905/">described</a> by Greek physicians. We don’t know for sure whether our ancestors were as bothered by it as much as we are today. But they were interested in what causes it.</p> <h2>What causes dandruff?</h2> <p>Dandruff is mainly caused by the yeast <em><a href="https://www.cell.com/cell-host-microbe/pdf/S1931-3128(19)30106-4.pdf">Malassezia</a></em>. The yeast lives on most people’s skin, either on the surface or in the opening of the hair follicle, the structure that surrounds a hair’s root and strand.</p> <p>The yeast feeds on sebum, the natural moisturiser secreted by your sebaceous glands to stop your skin drying out. These glands are attached to every hair follicle and the hair provides a dark, sheltered micro-environment ideal for the yeast to flourish.</p> <figure class="align-center zoomable"><a href="https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=1000&amp;fit=clip"><img src="https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=600&amp;h=520&amp;fit=crop&amp;dpr=1 600w, https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=600&amp;h=520&amp;fit=crop&amp;dpr=2 1200w, https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=600&amp;h=520&amp;fit=crop&amp;dpr=3 1800w, https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=45&amp;auto=format&amp;w=754&amp;h=653&amp;fit=crop&amp;dpr=1 754w, https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=30&amp;auto=format&amp;w=754&amp;h=653&amp;fit=crop&amp;dpr=2 1508w, https://images.theconversation.com/files/536003/original/file-20230706-22-6t0yr8.png?ixlib=rb-1.1.0&amp;q=15&amp;auto=format&amp;w=754&amp;h=653&amp;fit=crop&amp;dpr=3 2262w" alt="Diagram of skin cross-section showing hair follicle and other skin structures" /></a><figcaption><span class="caption">The yeast that causes dandruff lives on the skin surface and in the opening of the hair follicle.</span> <span class="attribution"><a class="source" href="https://www.shutterstock.com/image-vector/medical-education-chart-biology-hair-diagram-645657787">Shutterstock</a></span></figcaption></figure> <p>As the yeast grows, it releases molecules that irritate the skin and disrupts how the skin normally renews itself. This causes the cells to cluster together, appearing as white flakes. When there is excess sebum, this can mix with the cells and cause the dandruff to appear <a href="https://www.headandshoulders.co.in/en-in/healthy-hair-and-scalp/dandruff/yellow-dandruff">yellow</a>.</p> <p>The link between dandruff and yeast was made nearly 150 years ago. The person who first identified and described this yeast <a href="https://www.cell.com/cell-host-microbe/pdf/S1931-3128(19)30106-4.pdf">in 1874</a> was Louis-Charles Malassez (the yeast’s namesake).</p> <h2>Why do I have dandruff?</h2> <p>As <em>Malassezia</em> is found on most people, why do some people get dandruff and others don’t? This depends on a range of factors.</p> <p>These include the quality of your skin barrier. This may mean yeast can penetrate deeper if the skin is damaged in some way, for example, if it’s sunburnt. Other factors include your immunity, and external factors, such as which hair-care products you use.</p> <p>How <em>Malassezia</em> grows also depends on the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864613/">balance</a> of other microorganisms that live on your skin, such as bacteria.</p> <h2>How do I get rid of dandruff?</h2> <p>Dandruff is mostly treated with <a href="https://www.sciencedirect.com/science/article/abs/pii/S0939641123000292?via%3Dihub">anti-fungal</a> shampoos and scalp treatments to dampen down growth of <em>Malassezia</em>. The shampoos most commonly contain the anti-fungal agent <a href="https://pubmed.ncbi.nlm.nih.gov/34575891/">zinc pyrithione</a> (ZnPT for short). Other common anti-fungals in shampoos include selenium sulfide, ketoconazole and coal tar.</p> <p>You can also treat dandruff with scalp masks and scrubs that help restore the scalp barrier, by reducing inflammation and irritation. But as these may not have any anti-fungal action, your dandruff is likely to return.</p> <p>Home remedies <a href="https://www.healthline.com/nutrition/ways-to-treat-dandruff#7.-Omega-3s">include</a> tea tree oil, coconut or other oils, and honey. There is some evidence to support their use, mostly from <a href="https://pubmed.ncbi.nlm.nih.gov/35642120/">studies</a> that show extracts from botanical ingredients can reduce growth of the yeast in the lab. But there is great variation in the quality and composition of these ingredients.</p> <p>There is also the risk of making the problem worse by providing more oils that the yeast will enjoy, causing more imbalance to the scalp micro-organisms and leading to more irritation.</p> <p>So it’s best to stick with commercial products.</p> <h2>Why does my dandruff come back?</h2> <p>Your dandruff is likely to return unless the active ingredients in your shampoo can reach the right spot, at the right concentration, for the right amount of time needed to kill the yeast.</p> <p>Our <a href="https://pubmed.ncbi.nlm.nih.gov/36842718/">research</a> focussing on zinc pyrithione-based products showed these shampoos reached the skin surface. But they less-reliably ended up in the harder-to-reach hair follicles.</p> <p>We found the zinc pythione seemed <a href="https://pubmed.ncbi.nlm.nih.gov/35631659/">to target</a> the top of the follicles rather than deep into the follicles.</p> <p>So this may explain why dandruff keeps on coming back. Your shampoo’s active ingredient may not reach the yeast that causes your dandruff.</p> <p>We don’t yet know how we can encourage existing formulations to penetrate deeper into the follicles.</p> <h2>What about future treatments?</h2> <p>We’ll likely see new formulations of dandruff shampoos and scalp treatments that better deliver the active ingredient to where it’s needed – deeper into the hair follicles.</p> <p>We can also expect new active ingredients, such as <a href="https://pubmed.ncbi.nlm.nih.gov/28766952/">carbonic anhydrase</a> enzymes. These might target how the yeast grows in a different way to current active ingredients.</p> <p>We are also beginning to see the development of creams and lotions that aim to boost the health balance of flora of the skin, much like we see with similar products for the gut. These include pre-biotics (supplements or food for skin flora) or pro-biotics (products that contain skin flora). However we have <a href="https://www.mdpi.com/2079-9284/8/3/90/htm">much to learn</a> about these types of formulations.</p> <h2>In a nutshell</h2> <p>Dandruff is annoying, treatment helps, but you may need to repeat it. Hopefully, we can develop improved shampoos that better deliver the active ingredient to where it’s needed.</p> <p>But we need to strike a balance. We don’t want to eliminate all micro-organisms from our skin.</p> <p>These are important for our immunity, including preventing more disease-causing microbes (pathogens) from moving in. They also help the skin produce antimicrobial peptides (short proteins) that protect us from pathogens.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/201082/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/lorraine-mackenzie-1420658">Lorraine Mackenzie</a>, Associate Professor, Clinical and Health Sciences, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a> and <a href="https://theconversation.com/profiles/sean-mangion-1420661">Sean Mangion</a>, PhD Candidate, <a href="https://theconversation.com/institutions/university-of-south-australia-1180">University of South Australia</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/what-is-dandruff-how-do-i-get-rid-of-it-why-does-it-keep-coming-back-201082">original article</a>.</em></p>

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Promising Alzheimer’s drug offers hope for a bright future in treatment

<p>A remarkable and significant breakthrough in the fight against Alzheimer’s disease is ushering in a new era of hope and possibilities for patients grappling with early onset dementia.</p> <p>Scientists and researchers are celebrating this groundbreaking development, viewing it as a tremendous opportunity to transform the landscape of Alzheimer's treatment.</p> <p>The drug in question, donanemab, developed by Eli Lilly, has shown remarkable success in clinical trials and is anticipated to receive approval from the Food and Drug Administration later this year, according to a report in the <a href="https://nypost.com/2023/07/17/alzheimers-drug-donanemab-lowers-risk-of-dementia/" target="_blank" rel="noopener"><em>New York Post</em></a>.</p> <p>Individuals who participated in the donanemab trials experienced a remarkable 40% reduction in the risk of transitioning from mild cognitive impairment to mild or moderate dementia. This is an extraordinary advancement that brings renewed optimism to those affected by this devastating condition.</p> <p>Donanemab would be the third Alzheimer’s drug to emerge in recent months, following the introduction of Leqembi and Aduhelm. This is just the beginning of an exciting new chapter in the realm of molecular therapies for Alzheimer's, as expressed by Dr. Gil Rabinovici, director of the University of California San Francisco’s Memory and Ageing Centre, in an editorial for <em>JAMA</em>.</p> <p>Dr. Daniel Skovronsky, the chief scientific and medical officer at Lilly, has emphasised the significance of this breakthrough. He states, "This will be a very important and meaningful drug," as quoted in <em>Fierce Biotech</em>. Skovronsky further adds, "[T]here’s a huge opportunity here for patients." Such resolute optimism is inspiring, reflecting the tremendous potential this drug holds for transforming lives.</p> <p>Similar to Leqembi and Aduhelm, donanemab is a monoclonal antibody designed to target plaque in the brain, specifically the amyloid protein. These amyloid plaques are responsible for the propagation of another protein called tau, which contributes to the development of Alzheimer's disease.</p> <p>Notably, the donanemab trial also revealed that the drug slowed cognitive decline by an impressive 35% compared to a placebo in individuals with low to intermediate levels of tau protein in the brain. In fact, donanemab demonstrated superior efficacy in clearing amyloid plaques when compared to Aduhelm and Leqembi.</p> <p>Moreover, unlike Leqembi, which necessitates long-term usage, patients taking donanemab may follow a fixed-duration dosing schedule, potentially allowing some individuals to discontinue the treatment after a certain period. "I expect that many patients will be able to stop dosing even as soon as 12 months," Skovronsky affirmed. This stands as a significant departure from being prescribed a lifelong medication, providing an exciting and meaningful prospect for patients.</p> <p>While it is important to note that these new Alzheimer’s drugs do carry limitations and risks, medical experts remain cautiously optimistic. Donanemab, along with the other emerging drugs, has been associated with brain swelling and bleeding. Tragically, three individuals in the donanemab clinical trial lost their lives due to these side effects.</p> <p>The risk of brain swelling and bleeding is heightened among those carrying the APOE4 gene, which is associated with an increased susceptibility to Alzheimer’s. Furthermore, individuals with more advanced stages of the disease showed minimal to no benefit compared to those who received a placebo.</p> <p>As a result, it is possible that donanemab will be recommended primarily for individuals with low to intermediate levels of tau proteins, indicating milder forms of the disease.</p> <p>Nevertheless, Skovronsky and other medical experts maintain their optimism regarding the FDA's approval, expressing the urgent need for it to come to fruition. Skovronsky highlights, "Every day that goes by, there are some patients who pass through this early stage of Alzheimer’s disease and become more advanced, and they won’t benefit from treatment. That’s a very pressing sense of urgency."</p> <p>While challenges and risks remain, the emergence of donanemab and its potential approval by the FDA represents a beacon of hope for the millions of individuals and families affected by Alzheimer's disease. It symbolises the start of a new chapter in the fight against this debilitating condition, offering renewed prospects for a brighter future filled with effective treatments and improved quality of life.</p> <p><em>Image: Shutterstock</em></p>

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Big hair? Bald? How much difference your hair really makes to keep you cool or warm

<p><a href="https://theconversation.com/profiles/theresa-larkin-952095">Th<em>eresa Larkin</em></a><em>, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p>We have <a href="https://theconversation.com/health-check-why-does-womens-hair-thin-out-39126">millions</a> of hair follicles on our body, including around 100,000 on our scalp.</p> <p>This might sound like a lot of hair, yet humans are described as “hairless”. We have evolved to be the only mammals with a relatively hairless body, but still with scalp hair.</p> <p>So how does your hair affect your body temperature when it’s hot or cold?</p> <p>Compared with other animals, our hair does not have as much influence on keeping us warm or cool as you might think.</p> <h2>Essential to our survival</h2> <p>Our brain function and body’s metabolism depend on an optimal temperature of around 37℃. Thermoregulation maintains this body temperature, even when we are exposed to a hotter or colder external temperature.</p> <p>For non-human mammals, body hair or fur plays a role in protecting against environmental cold or heat.</p> <p>For instance, a heavy fur coat helps keep a polar bear <a href="https://polarbearsinternational.org/polar-bears-changing-arctic/polar-bear-facts/adaptions-characteristics/">warm</a> in the cold. But fur also keeps an animal cool in the heat because it can <a href="https://www.jstor.org/stable/25064866">absorb or reflect</a> radiant heat.</p> <p>Scientists think this is why humans have kept hair on our heads. Our heads are exposed to the most heat from the sun, and scalp hair keeps our heads cool.</p> <p>Research published just last week <a href="https://www.pnas.org/doi/10.1073/pnas.2301760120">suggests</a> curly hair provides the best heat protection. That’s because curly hair’s thicker layer of insulation reduces the amount of sun that reaches the scalp.</p> <h2>But hair is not the only factor</h2> <p>When humans moved from living in the jungle to the savannah, they needed to walk and run long distances in the sun. This meant they needed a way to handle the increased body temperature that comes with physical activity in the heat.</p> <p>Sweating is the best way to lose heat and cool down, but the presence of hair reduces sweating and heat loss from the skin.</p> <p>So humans evolved to <a href="https://www.pnas.org/doi/10.1073/pnas.1113915108">lose body hair</a> to be better adapted to exercising in the heat. Fewer hair follicles in our skin made room for more sweat glands. This made our skin optimal for sweat evaporation – and the <a href="https://theconversation.com/want-to-keep-cool-on-hot-summer-days-heres-how-34489">heat loss</a> that goes with it – to keep us cool.</p> <h2>So what’s best in the heat?</h2> <p>You might think removing body hair or having a bald head is best for sweating and keeping cool when exercising in the heat. However, it’s not that simple.</p> <p>Removing head hair would increase the <a href="https://www.pnas.org/doi/10.1073/pnas.2301760120">amount of sun</a> that reaches your scalp. This means you would need to <a href="https://pubmed.ncbi.nlm.nih.gov/20683812/">sweat more</a> during exercise in the sun to reduce an increase in body temperature, but not by much.</p> <p>In fact, it’s the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667044/#:%7E:text=The%20body%20hair%20is%20advantageous,heat%20removal%20during%20heat%20stress.">least hairy</a> areas of our body that have the highest sweat rates during exercise. These are our forehead, neck, feet and hands.</p> <p>So the best way to keep cool in the heat is to keep these areas uncovered (but still use sunscreen). Removing body hair will not have a large impact on your overall sweat rate.</p> <h2>How about when it’s cold?</h2> <p>Our body hair and head hair theoretically have a role in keeping us warm, but the effects are minimal.</p> <p>When we are cold, the muscles of the hair follicles on the body contract to cause the hairs to stand straight. This is an attempt to trap heat close to the body and we see this as goosebumps. However, because our body hair is so thin, this does not have a big effect in keeping us warm.</p> <p>Our head hair can prevent some heat loss from the head, but again this is limited.</p> <p>When it’s cold, heat can still be lost through the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4667044/#:%7E:text=The%20body%20hair%20is%20advantageous,heat%20removal%20during%20heat%20stress.">skin of the head</a> regardless of your hairstyle.</p> <p>The scalp also has only a very thin layer of fat compared to the rest of our skin, so our head has less insulation to protect against the cold.</p> <p>A warm hat or beanie is the only way to prevent too much heat lost from the head.</p> <h2>In a nutshell</h2> <p>Our head and body hair, or lack of it, does have a small role in how you maintain your body temperature.</p> <p>But overall, your hairstyle does not influence whether you feel warm or cool.<!-- Below is The Conversation's page counter tag. Please DO NOT REMOVE. --><img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/201380/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /><!-- End of code. If you don't see any code above, please get new code from the Advanced tab after you click the republish button. The page counter does not collect any personal data. More info: https://theconversation.com/republishing-guidelines --></p> <p><em><a href="https://theconversation.com/profiles/theresa-larkin-952095">Theresa Larkin</a>, Associate professor of Medical Sciences, <a href="https://theconversation.com/institutions/university-of-wollongong-711">University of Wollongong</a></em></p> <p><em>Image credits: Shutterstock</em></p> <p><em>This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/big-hair-bald-how-much-difference-your-hair-really-makes-to-keep-you-cool-or-warm-201380">original article</a>.</em></p>

Beauty & Style

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Embrace grey hair with our simple healthy hair tips

<p>While in the past going grey may have been seen as a negative of the ageing process, today women are embracing this as a stamp of wisdom. And why not? It’s en vogue and can look really attractive too. Thank goodness the days of “having” to hide your natural colour are gone! But just because you’re going natural, doesn’t mean there’s no effort involved. Knowing how to care for and style your grey locks is key and can make all the difference between “stylish and sixty-plus” and “stuffy and sixty-plus”. Read on for our top tips and tricks for healthy, happy hair.</p> <p><strong>Focus on your cut</strong> – A great cut is essential for any hair colour but especially for grey hair. Chances are good that you may have been dyeing your hair in the months/years leading up to embracing grey… so a decent chop may increase the health and vitality of your locks. Speak to your hairdresser about a style that suits both your face shape and lifestyle.</p> <p><strong>Swap your shampoo</strong> – Grey hair is far more prone to breakage and can also become quite dry and coarse. Ensuring that you’re using a moisturising shampoo at every wash can help keep strands in good condition.</p> <p><strong>Condition well</strong> – If you’ve been wary of conditioner in the past due to your hair being on the oily side, now is the time to become friendly again. Conditioning with a moisturising formula is essential after every shampoo. If you’re still nervous about hair becoming oily, you can try a shampoo for “normal” hair, which will nourish without weighing hair down.</p> <p><strong>Treat yourself to an at-home treatment</strong> – Once a fortnight, treat your hair with a shampoo specifically formulated for grey hair. After washing and conditioning, apply a clear colour glaze or gloss which is designed to coat the cuticle, boosting shine and general vitality.</p> <p><strong>Take care when styling</strong> – As it’s prone to dryness and breakage, applying a thermal protectant to your hair before heat styling is a great way to prevent damage from occurring. Simply comb through hair and style as normal. It’s also a good idea to try and have a day or two off a week from using your hairdryer/hot implements to give hair a good break.</p> <p><em>Images: Getty</em></p>

Beauty & Style

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Fans fume as classic film undergoes censorship treatment

<p>Film fanatics are in outrage after discovering an unannounced edit in William Friedkin’s 1971 classic movie, The French Connection.</p> <p>The scene causing the trouble comes just 10 minutes into the drama, when two characters - Gene Hackman’s ‘Popeye’ Doyle and Roy Scheider’s Buddy ‘Cloudy’ Russo - are having a conversation, and one of them uses a racial slur. </p> <p>The sequence was removed, and the new edited version cuts to the latest in the conversation, omitting the part with the slur. </p> <p>Disney has been the subject of blame for the move - as the company took over Fox in 2019 and subsequently the rights to the film - with fans accusing them of censoring the scene in the United States, while in the United Kingdom and Canada, the unedited version of the film is still available for streaming on Disney+.</p> <p>Most took to social media to share their complaints, with the majority in agreement that Disney had missed the mark, and The Film Magazine’s Joseph Wade even calling it “corporate vandalism”.</p> <p>“In cases such as this, ‘Censor’ takes the place of ‘Vandalise’,” he tweeted. “They have vandalised a piece of art.”</p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Disney Censor 'The French Connection' (1971)</p> <p>In cases such as this, "Censor" takes the place of "Vandalise".</p> <p>They have vandalised a piece of art. This is corporate vandalism no matter how said corporation spins the language. <a href="https://t.co/yxl1o2RsMU">pic.twitter.com/yxl1o2RsMU</a></p> <p>— Joseph Wade (@JoeTFM) <a href="https://twitter.com/JoeTFM/status/1666327940072722434?ref_src=twsrc%5Etfw">June 7, 2023</a></p></blockquote> <p>“At the risk of being like ‘nooo, my precious n-word,’ the uncensored FRENCH CONNECTION should be the only one in circulation, whether on TV or in theatres,” one user said. “I don't think it's a stretch to say that Friedkin knew exactly what having his detective protagonist use it said about him.”</p> <p>One user went on to share a clip of Hackman discussing the scene - and slur - in question, in which the actor claimed he “protested somewhat”, before sharing his belief that it was part of “who the guy is”. </p> <blockquote class="twitter-tweet"> <p dir="ltr" lang="en">Gene Hackman speaking in 2012 about the controversial line from French Connection. <a href="https://t.co/l45DBP9DvD">pic.twitter.com/l45DBP9DvD</a></p> <p>— oneilla (@oneilla828) <a href="https://twitter.com/oneilla828/status/1666439477403811840?ref_src=twsrc%5Etfw">June 7, 2023</a></p></blockquote> <p>“The censorship of The French Connection is shameful if true,” another agreed.</p> <p>“Thank God,” a frustrated - and sarcastic - fan added, “now I can finally show my 6 year old child The French Connection without any worries”.</p> <p>One Twitter user wrote of how “it speaks badly for film preservation that even a Best Picture winner isn't immune from the clutches of Disney”, and how they’d prefer to watch the film “the way it was intended to be watched, thank you very much.”</p> <p><em>Images: Twentieth Century Fox</em></p>

Movies

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10 best tips for gracefully growing out grey hair

<h2>Pro tips that make going grey so much better</h2> <p>There’s no avoiding it. At some point, you will have to deal with grey hair. Of course, how you deal with it is up to you. Some women start growing out grey hair as soon as it begins to appear. Others begin their journey by pulling out greys and then spend years dyeing it before deciding it’s too much of a hassle to do the constant cover-up. Even if you’ve found the <a href="https://www.readersdigest.com.au/healthsmart/beauty/how-to-find-the-best-hair-colour-for-your-skin-tone" target="_blank" rel="noopener">best hair colour for your skin tone</a>, having to touch up your roots every four to six weeks can get old. No matter what your path is, going grey isn’t for the faint of heart.</p> <p>“Many women find it challenging to grow out grey hair,” says hairstylist Krysta Biancone. “This is because it usually occurs gradually, so the transition from natural hair colour to grey hair is not easy.”</p> <p>But it’s not all doom and gloom when it comes to going grey. In fact, it can be incredibly empowering, liberating and downright gorgeous when you make it to the finish line, and it can even make you look younger. But first, there are a few things you need to know. We asked top hairstylists around the country to divulge their best tips for making this transition as easy as possible.</p> <h2>Add highlights</h2> <p>It might sound counterintuitive, but adding subtle colour can make the transition to grey more seamless. “When you first decide you’re nearly ready to go natural, a step in the right direction would be to start going lighter. That way, the roots grow in a little more gracefully,” says hair stylist and colourist, Kali Ferrara. “This can be done easily by a skilled colourist, with a lighter base colour in conjunction with highlights.”</p> <p>One word of warning: steer clear of warmer colours like reds and strawberry blondes when growing out grey hair. Ferrara says these hues could backfire and show even more contrast with your roots.</p> <h2>Go a little darker</h2> <p>On the flip side, you could choose lowlights. But instead of adding a shade that’s slightly darker (which is normally what you’d do with lowlights), try to match your non-grey hair colour. This will help blend without adding a brand-new shade to the mix. “Lowlights create some contrast and will give hair a more salt-and-pepper look that can be very becoming,” says celebrity hairstylist Gina Rivera. Just be sure not to go darker than your hair colour, says Rivera. Doing so can create too much contrast and bring more attention to the fact that you are transitioning to grey, which won’t look good in photos or in real life.</p> <h2>Chop it off</h2> <p>Ready for a big change? Ferrara recommends growing your roots as long as you possibly can and then getting a super-short haircut to get rid of all the leftover colour. How short you go is totally up to you. A pixie cut can be chic and low-maintenance, but if you’ve never had short hair, that could be too big of a change. A short bob looks good on just about anyone, so that may be your best bet, though a stylist will be able to help you determine just how short will be flattering for your face shape. In general, slimmer faces tend to look great with hair that hits just under the jawbone, while fuller faces may want to go slightly longer (think a few centimetres below the jaw).</p> <p>“While this can be a dramatic change, it can also be just the new look you may be looking for!” Ferrara says. “Think of your natural hair colour as a new adventure – a new, liberated you.”</p> <h2>Cover roots as they grow in</h2> <p>If you’re growing out grey hair but your roots are driving you nuts, there are a few ways you can hide them. One easy solution is to cover them with a headband, hat or chic scarf. Another option is root spray or powder. “These products can mask the roots very effectively,” says master stylist Lorrene Conino. “Just spray the exposed areas after you style your hair.”</p> <p>Just shake the bottle well, hold it about 15 centimetres from your roots and spritz it on. These products offer instant coverage on grey hair without an expensive trip to the salon.</p> <h2>Don’t slack on trims</h2> <p>If you can’t bring yourself to do a big cut, regular haircuts (even little ones!) can help make the process go faster too. Aim for a trim every six to eight weeks. This will help you get rid of split ends and maintain healthy hair during your growing-out period, says hairstylist Nia Jones. After all, she explains, you may as well keep your hair looking as good as possible as you go through this tricky transition. Another bonus? Even if you aren’t getting a drastic cut, snipping a bit each time will get rid of old colour.</p> <h2>Prevent brassiness</h2> <p>As more and more grey starts growing in, make sure those strands look as good as possible. Although grey hair is less vibrant than hair of other colours, it still can become dull and uneven if not properly cared for. Sun exposure, washing hair with water that has a high mineral content, and improper hair care are just a few reasons grey locks can turn brassy. Luckily, there’s a quick fix: using shampoo and conditioner designed specifically for silver or white hair can help tone down brassiness by balancing out the warm undertones, says Biancone.</p> <p>You can also include purple toning products into your maintenance routine. Why purple? To understand how a purple product works, you need to know a bit about colour theory. Essentially, on the colour wheel, purple is opposite of yellow. This means that purple shampoo or toner helps to neutralise unwanted yellow or brassy tones that can come along with greys. Try adding toning drops to your shampoo or conditioner once a week to keep your hair the colour you want it. Taking this small precaution when caring for grey hair can help create luscious-looking locks with longevity.</p> <h2>Go big on moisture</h2> <p>The texture of grey hair is quite different from the hair of your youth. George Papanikolas, a celebrity hairstylist, explains that it’s typically more coarse, frizzy and dehydrated. To combat this, he recommends arming your strands with moisturising products that will keep it silky and shiny.</p> <h2>Don’t try to remove hair dye on your own</h2> <p>Let’s say you’ve been dying your hair to cover up those greys but wish you hadn’t. Well, even if you’ve just been using root touch-up kits as new greys grow in, you should never try to lift or remove hair dye on your own. “Chemicals are typically used to remove colour, and you need to know what you are doing,” warns Rivera. “If you don’t, you could end up really damaging your hair.” If this is a route you’re intent on exploring instead of waiting for the colour to grow out, book an appointment with a professional. Just be aware that removing hair dye is tricky and often takes multiple appointments.</p> <p>For an easier, much gentler option, try using a clarifying shampoo to lighten the dye on your strands, says Jones. These shampoos are formulated to remove excess buildup and give you a deep clean, but they may also help wash away some colour. Just don’t use them more than once a week. These products give hair a deep clean, and using them too often can strip your strands of natural oils that add hydration.</p> <h2>Experiment with new styles</h2> <p>Whether you’re trying to cover up the grey or want to embrace it, Jones suggests playing with different styles outside of the boundaries of your everyday look – ie, a ponytail, a different part that flatters your face shape or a brushed-back style that ‘hides’ roots. Changing things up allows you to play with your style, and it also makes growing out grey hair look cool and intentional. Who says blondes have all the fun?!</p> <p><em>This article originally appeared on <a href="https://www.readersdigest.co.nz/healthsmart/beauty/10-best-tips-for-gracefully-growing-out-grey-hair" target="_blank" rel="noopener">Reader's Digest</a>.</em></p> <p><em>Images: Getty</em></p>

Beauty & Style

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8 hair washing tips to transform your tresses this winter

<p dir="ltr">One curly-haired influencer has shared her secrets to happy and healthy hair with the world, promising small changes that “make a big impact” over all. </p> <p dir="ltr">In a video posted to her social media accounts, Jennie - who goes by ‘The Curly Carr’ online - stressed the importance of learning to properly cleanse hair, and the benefits it can have on the likes of “hair health, definition, shine, volume, and growth”.</p> <p dir="ltr">As she explained, she too used to be guilty of just hopping in the shower, quickly slathering her hair in shampoo, and rinsing to get the job done. </p> <p dir="ltr">“I had no clue what I was doing!” she confessed. “Seems like such a small thing, but makes a big impact.”</p> <p dir="ltr">But luckily for Jennie - and anyone else fortunate enough to hear her top tips - she did learn what she should be doing, working her way towards the luscious locks many dream of, before setting out on her mission to help others on their hair journey.</p> <p dir="ltr">And in just eight simple steps, that won’t cost you a fortune in new products, Jennie has shared her findings, as well as some helpful advice to help with the transition from quickfire wash to thorough and effective hair care. </p> <p dir="ltr">Step one was straightforward enough, with Jennie noting that it’s important to “make sure your hair is thoroughly wet all the way through”. According to some experts, a good wetting with warm water helps hair to open up, allowing for a better conditioning process later on. </p> <p dir="ltr">Step two called for emulsifying shampoo in your hands before it goes anywhere near your head. Essentially, rub it between your hands until it froths up - once you’ve got the suds, it’s time to move on to the hair. </p> <p dir="ltr">Step three instructed hair hopefuls to massage their heads. But, as Jennie advised, do it “with the pads of your fingers, don’t use your nails”. Be gentle up there, just like you would be to your face. </p> <p dir="ltr">Step four followed directly on from three, with the instruction to message “all around your head” and to make sure everything got a good clean. Jennie noted that it may take anywhere from 3-5 minutes, but it would all be worth it to have your scalp cleansed. </p> <p dir="ltr">Step five had Jennie calling for the lengths of hair to be remembered, as “it’s not just your scalp getting buildup with products, dirt, and oil”.</p> <p dir="ltr">Step six was to use a <a href="https://www.priceline.com.au/product/189080/lady-jayne-restorative-scalp-brush-silicon-bristles-1ea">shampoo brush/scalp brush</a>, particularly for those who - like Jennie herself - tended to go a few days between washes, or did a pre-shampoo process. </p> <p dir="ltr">Step seven was another one many would be familiar with, as Jennie noted the importance of making sure all shampoo had been thoroughly washed out “before moving on to conditioner!” </p> <p dir="ltr">And last but not least, step eight instructed viewers to listen to their scalps, as they’d know best when it was time for the next all-important wash. </p> <p dir="ltr">“Your hair can always be refreshed,” Jennie explained, “but if your scalp is dry, itchy, and you can see buildup, it’s time to wash!”</p> <blockquote class="instagram-media" style="background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);" data-instgrm-captioned="" data-instgrm-permalink="https://www.instagram.com/reel/CnmLyOjKDC1/?utm_source=ig_embed&amp;utm_campaign=loading" data-instgrm-version="14"> <div style="padding: 16px;"> <div style="display: flex; flex-direction: row; align-items: center;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;"> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;"> </div> </div> </div> <div style="padding: 19% 0;"> </div> <div style="display: block; height: 50px; margin: 0 auto 12px; width: 50px;"> </div> <div style="padding-top: 8px;"> <div style="color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;">View this post on Instagram</div> </div> <div style="padding: 12.5% 0;"> </div> <div style="display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;"> <div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);"> </div> <div style="background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;"> </div> <div style="background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);"> </div> </div> <div style="margin-left: 8px;"> <div style="background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;"> </div> <div style="width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);"> </div> </div> <div style="margin-left: auto;"> <div style="width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);"> </div> <div style="background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);"> </div> <div style="width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);"> </div> </div> </div> <div style="display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;"> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;"> </div> <div style="background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;"> </div> </div> <p style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;"><a style="color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;" href="https://www.instagram.com/reel/CnmLyOjKDC1/?utm_source=ig_embed&amp;utm_campaign=loading" target="_blank" rel="noopener">A post shared by Jennie 🌷 | Curly Hair Care and Simple Hairstyle Tutorials (@the.curly.carr)</a></p> </div> </blockquote> <p dir="ltr"><em>Images: TikTok</em></p>

Beauty & Style

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Unlocking the Silver Revolution: The Truth About Grey Hair and the Empowering Journey to Embrace the Grey

<p>In a recent poll by midlife connection organisation, Connected Women reveals that two-thirds of women over the age of 50 haven’t embraced their grey hair (67%). With hair starting to go grey in our 30s and 40s, that’s a long time to hide those pesky greys!</p> <p><strong>What causes grey hair? </strong></p> <p>According to Harvard Health, hair doesn’t ‘turn’ grey. Once a strand of hair is a particular colour, it will stay that way unless it is dyed. After the age of 35, hair follicles produce less colour, so when that strand of hair falls out it will be more likely to grow back grey.</p> <p><strong>Can stress cause grey hair? </strong></p> <p>There is very little evidence to indicate that this is true, however, research shows that in mice, in response to a fight or flight situation, hair follicles are impacted and the pigmentation-producing stem cells can be lost. Without stem cells available to produce pigment cells, the hair will go grey.</p> <p>So, can we now legitimately blame our grey hairs on our kids, or our husbands.</p> <p><strong>What happens when you pluck your grey hairs out? </strong></p> <p>Don’t do it! Not only will it simply grow back grey, but according to Trey Gillen, hairstylist and creative director of education at SACHAJUAN, doing so can also traumatise the follicles which could mean NO hair grows back.</p> <p><strong>When is the right time to go grey?</strong></p> <p>This is something that only you can decide. If your hair is dark brown or black, your greys will be more noticeable, so you’ll need to have regular (two to four weekly) trips to the hairdresser to cover them up. At some point you will most likely grow weary of trying to stem the tide and it will be time to just embrace the grey. You will know when you’ve had enough!</p> <p>If you have lighter hair, then your greys will be much less noticeable. Lighter hair gives you a much longer window between coloring appointments in the initial stages of going grey, and later you can use the greys as ‘herringbone highlights’ as per Sarah Jessica Parker’s beautiful mane, which is wonderful way to gracefully embrace going grey.</p> <p><img src="https://oversixtydev.blob.core.windows.net/media/2023/05/Phoebe-headshot-EDITED.jpg" alt="" width="1280" height="720" /></p> <p><span style="box-sizing: border-box; font-weight: bolder; color: #212529; font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji'; font-size: 16px; background-color: #ffffff;"><span style="box-sizing: border-box; caret-color: #212529;"><em style="box-sizing: border-box;">Phoebe Adams is the founder of Connected Women, an organisation providing a community for women over 50 to connect with each other and build meaningful friendships. With a rapidly growing community in Perth, Sydney, Wollongong, and Melbourne, Connected Women provides a safe and welcoming space for women to come together and share experiences. To learn more about the organisation and how you can get involved, visit <a style="box-sizing: border-box; color: #258440; text-decoration-line: none; background-color: transparent; transition: all 0.2s ease-in-out 0s;" href="https://www.connectedwomen.net/" target="_blank" rel="noopener">connectedwomen.net</a>.</em></span></span></p> <p><em><span style="box-sizing: border-box; font-weight: bolder; color: #212529; font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol', 'Noto Color Emoji'; font-size: 16px; background-color: #ffffff;"><span style="box-sizing: border-box; caret-color: #212529;"><span style="box-sizing: border-box;"><span style="color: #000000; font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, Oxygen, Ubuntu, Cantarell, 'Open Sans', 'Helvetica Neue', sans-serif; font-size: medium; font-weight: 400;">Image credits: Getty Images</span></span></span></span></em></p>

Beauty & Style

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5 simple tips to fix dry hair

<p>As we age, our hair is just one of the parts of our body that goes through a drastic change. Aside from the obvious (going grey), it also becomes thinner, drier, duller, and you may experience some hair loss.</p> <p>But thankfully, you can take steps to ensure your hair looks as healthy as possible no matter what your age.</p> <p>Here are five tips to help you rejuvenate and re-moisturise dry, dull hair.</p> <p><strong>1. Get the temperature right</strong></p> <p>You might like your showers extra hot, but too much heat can force the hair shalt open, and if your hair is dry or damaged, the shaft won’t be able to close fully and the moisture will seep right out. Instead, keep the water warm during washing then finish with a cool rinse to make your hair look shinier.</p> <p><strong>2. Don’t over-wash</strong></p> <p>Using shampoo every day will strip your hair of its healthy natural oils, thus drying it out. Try to use it only every second day, using conditioner in between to add some moisture.</p> <p><strong>3. Raid the kitchen</strong></p> <p>The secret to healthy, shiny hair could be lying in your kitchen. For a rejuvenating, vitamin-packed hair mask, simply mash a super ripe avocado with some olive oil. Apply to your hair, leave for 20 minutes and then rinse off – it’s an easy, natural way to restore moisture and shine.</p> <p><strong>4. Turn off the tools</strong></p> <p>Your hair dryer or straightener may make life easier when it comes to styling, but it’s not doing damaged hair any help. If you absolutely can’t live without them, at least invest in the best tools you can afford.</p> <p>And when choosing a straightener or hair iron, don’t go any hotter than 185 degrees – any higher and your hair may become more damaged. The same goes for hair dryers – avoid the temptation to switch it up to the hottest setting, and before subjecting your hair to any dryers or straighteners, treat it with a heat protectant spray.</p> <p><strong>5. Book a trip to the salon</strong></p> <p>It might not be that your hair is dry, but rather that the ends of your hair are dry, split and in need of a cut. A good way to judge how much you need to trim is by seeing how quickly your hair dries. If the ends air-dry almost immediately while the rest of your hair remains wet, those ends need to go.</p> <p><em>Images: Getty</em></p>

Beauty & Style